Alkermes: Entry Into A Material Definitive Agreement, Financial Sta

Item 1.01 Entry into a Material Definitive Agreement.Term Loan Credit FacilitiesOn August 12, 2026, Alkermes plc (the “Company”) entered into Amendment No. 1 to Credit Agreement (the “Amendment”), which amends the Credit Agreement, dated as of February 12, 2026 (the “Credit Agreement”), among the Company, as the TopCo Borrower, Alkermes, Inc., as the U.S. Borrower, Alkermes Finance LLC, as the U.S. Co-Borrower, JPMorgan Chase Bank, N.A., as Administrative Agent, Joint Lead Arranger and Joint Bookrunner, BofA Securities, Inc., as Joint Lead Arranger and Joint Bookrunner, and the lenders party thereto.The Credit Agreement provides for a senior secured term loan A facility (the “TLA Facility”) in an outstanding principal amount of $745,312,500.00 and a senior secured term loan B facility (the “TLB Facility”) in an outstanding principal amount of $773,062,500. The TLA Facility matures on February 12, 2031 and the TLB Facility matures on August 12, 2031.The Amendment reduces the interest rate spread (i) under the TLA Facility by 0.75% and (ii) under the TLB Facility by 0.50%, among other changes. After giving effect to the Amendment, borrowings under the TLA Facility will bear interest at an annual rate of, at our option, either (i) the Term SOFR Rate (as defined in the Credit Agreement), plus a Secured Net Leverage Ratio (as defined in the Credit Agreement)-based margin, ranging from 1.75% to 2.25% per annum, or (ii) the Alternate Base Rate (as defined in the Credit Agreement) plus a Secured Net Leverage Ratio-based margin, ranging from 0.75% to 1.25% per annum. Borrowings under the TLB Facility will bear interest at an annual rate of, at our option, either (i) the Term SOFR Rate plus a margin of 2.25% per annum, or (ii) the Alternate Base Rate plus a margin of 1.25% per annum.The foregoing description of certain provisions of the Amendment and the underlying Credit Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of the Amendment, a copy of which is filed as Exhibit 10.1 to this Current Report on Form 8-K and incorporated by reference into this Item 1.01, and the Credit Agreement, a copy of which was filed as Exhibit 10.1 to the Company’s Current Report on Form 8-K filed on February 12, 2026. Item 9.01 Financial Statements and Exhibits. (d) ExhibitsEXHIBIT INDEX Exhibit No. Description 10.1 Amendment No. 1 to Credit Agreement, dated as of August 12, 2026 by and among Alkermes plc, as the TopCo Borrower, Alkermes, Inc., as the U.S. Borrower, Alkermes Finance LLC, as the U.S. Co-Borrower, JPMorgan Chase Bank, N.A., as Administrative Agent, and the arrangers and lenders party thereto. 104 Cover page interactive data file (embedded within the Inline XBRL document). 2 SIGNATUREPursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. ALKERMES PLC Date: August 12, 2026 By: /s/ David J. Gaffin David J. Gaffin Secretary 3

Alkermes: Entry Into A Material Definitive Agreement, Financial Sta

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